Research Fellow (CVMD/LH)

Job Description

Heart diseases is the number one leading cause of mortality worldwide along with cancer. The Cardiovascular and Metabolic Disorders (CVMD) Programme houses state-of-the-art technologies for profiling mitochondrial function and metabolic adaptations in human patients and other model organisms, and undertakes translational and clinical research in cardiovascular and metabolic disorders. The program has a strong track record in publication in top tier journals, successful commercialisation efforts leading to spin-offs, as well as nurturing early career researchers on to independent academic or industry positions. 

Microproteins encoded by cryptic small open reading frames (smORFs) are rapidly becoming recognized as an untapped resource of new genes with regulatory functions in cardiometabolic and mitochondrial biology. The Ho lab in Duke-NUS is a leader in microprotein discovery, functional characterization and therapeutic development. We are establishing a program focusing on microproteins in heart failure, with an emphasis on those that regulate metabolism and inflammation. The goal of this program is to discover clinically relevant candidates that can be fast tracked for clinical development. The lab uses a combination of bioinformatics, biochemistry, animal modelling, Crispr screening and single-cell omics in human and mouse systems to understand how mito-SEPs regulate cellular processes related to energy production. More information can be found at www.ho-lab.org. 

The ideal candidate should have expertise and interest in any of the following areas:

• Mitochondrial biochemistry or bioenergetics
• Cardiac function and physiology including mouse models 
• Cardiac regeneration and inflammation
• Bioinformatics analyses of ribosome profiling data and disease causative gene identification
• Crispr screening

The Research Fellow will conduct research to address how candidate microproteins contribute to heart failure in humans and rodent models. He or she will be responsible for planning, organising, conducting, communicating research studies and manuscript preparation. The selected candidate will receive extensive and specialised training both within the lab and with our extensive network of external collaborators. The candidate will also receive opportunities to develop independent research questions and to obtain grant funding for career progression. The Ho lab offers a collaborative, nurturing and dynamic environment for growth. Team members value camaraderie, collaboration and believe that the sum strength of a team is more than that of its individual members.  

Job Requirements

• PhD in a related scientific area or post-graduate medical degree with at least 3 years’ relevant research experience and training. 
• Track record of productivity with high impact publications in your field of study.
• Conceptual, critical and analytical thinking.
• Autonomy and goal-directedness, able to organise and prioritise, with strong problem-solving skills
• A strong team player who is open-minded, energetic, highly motivated and can work collaboratively in an interdisciplinary team and diverse workforce.

We regret that only shortlisted candidates will be notified.

More Information

Location: Outram Campus

Organization: Duke-NUS Medical School

Department : Office of Research

Employee Referral Eligible: No

Job requisition ID : 21361