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Research Fellow (Biological Sciences)

Date: 10-Sep-2022

Location: Kent Ridge Campus, SG

Company: National University of Singapore

Job Description

The Tan lab is looking for a post-doctoral candidate who will work with Assistant Professor Tan Yong Zi on biochemistry and structural biology under a project entitled Understanding the Structure and Function of Mammalian Membrane Proteins Involved in Human Diseases.

While membrane proteins only make up around 20% of the proteome, they constitute around 60% of drug targets. However, high resolution structural information is severely lacking for them, with only about 2% of the structures deposited in the public protein database (PDB) being annotated as membrane proteins. The Tan lab (www.tyzlab.com) strives to fill in this gap by targeting membrane proteins involved in human diseases such as cancer and diabetes. Our forte is using state-of-the-art single-particle cryogenic electron microscopy (cryo-EM) to obtain high-resolution atomic structures of these membrane proteins. We also actively work on methods development in cryo-EM that will help us answer our biological questions.

The Tan lab is generously funded by the NUS Presidential Young Professorship under the Department of Biological Sciences, NUS. We are a core member of the Centre for BioImaging Sciences' (CBIS), and have access to high-end cryo-EM microscopes, including a Titan Krios with K3 direct detector and energy filter.

Main Responsibilities
•    Lead structural projects from protein expression, protein purification, activity assay, cryo-EM imaging, data processing and model building

Application Requirements
•    Candidates must uphold values of scientific integrity, honesty, teamwork and pride in their work
•    PhD in Biology/Biochemistry/Biophysics/Biotechnology or related field
•    Experience with bacterial, insect and mammalian cell culture work is not essential but favoured
•    Experience in protein purification experience is required
•    Programming (such as Python) skills not essential but favoured
•    Structural biology experience not essential but favoured

Interested candidates please contact Dr. Tan Yong Zi at yztan(at)nus.edu.sg. Please provide a CV and names and contact of three referees.

Qualifications

•    Candidates must uphold values of scientific integrity, honesty, teamwork and pride in their work
•    PhD in Biology/Biochemistry/Biophysics/Biotechnology or related field
•    Experience with bacterial, insect and mammalian cell culture work is not essential but favoured
•    Experience in protein purification experience is required
•    Programming (such as Python) skills not essential but favoured
•    Structural biology experience not essential but favoured

Covid-19 Message

At NUS, the health and safety of our staff and students are one of our utmost priorities, and COVID-vaccination supports our commitment to ensure the safety of our community and to make NUS as safe and welcoming as possible. Many of our roles require a significant amount of physical interactions with students/staff/public members. Even for job roles that may be performed remotely, there will be instances where on-campus presence is required.

Taking into consideration the health and well-being of our staff and students and to better protect everyone in the campus, applicants are strongly encouraged to have themselves fully COVID-19 vaccinated to secure successful employment with NUS.

More Information

Location: [[Kent Ridge Campus]]

Organization: [[National University of Singapore]]

Department : [[Department of Biological Sciences]]

Employee Referral Eligible: [[No]]

Job requisition ID : 16870