Job Description

The Mechanobiology Institute (MBI) at the National University of Singapore (NUS) is a leading multi-disciplinary institute devoted to developing new paradigms for understanding biological functions in health and diseases from the perspective of cell, tissue and organ mechanics/dynamics and mechano-signal transduction. The institute operates on a fully integrated open-lab philosophy, with an extensive infrastructure supported by core facilities dedicated to technology such as state-of-the-art light microscopy, nano- and micro- fabrication, and computing

We are seeking a Research Fellow with expertise in transmission electron microscopy (TEM) to join our research team, focusing on the morphological characterization of biological samples. This role is part of our broader mechanobiology research program, which investigates how cells and tissues adapt and change in response to aging and their physical microenvironment.

This position offers an excellent opportunity to apply and expand TEM expertise in a collaborative research environment, contributing to high-resolution studies of mechanobiology, aging, and cell–microenvironment interactions. The successful candidate will conduct TEM-based investigations, refine sample preparation workflows, and work with complementary bioimaging techniques. The position offers full access to state-of-the-art TEM platforms and opportunities to contribute to ongoing biomedical research projects. As projects progress, in-house training will be provided in advanced methods, including cryo-TEM, cryo-electron tomography (cryo-ET), and correlative light and electron microscopy (CLEM)

The selected candidate's key responsibilities will include:

• Prepare biological samples for TEM, including fixation, staining, sectioning, embedding, and mounting.
• Perform TEM imaging and support data acquisition and basic image analysis.
• Maintain clear records of sample preparation protocols, imaging parameters, and results.
• Share knowledge and provide guidance on sample preparation and imaging workflows as needed.
• Collaborate with colleagues across disciplines to integrate TEM findings into broader research studies.
• Assist in training and supporting junior researchers in TEM techniques.

Qualifications

• PhD in Biology, Biomedical Sciences, Biophysics, or a related life science discipline.
• Practical experience in TEM sample preparation and imaging of biological specimens.
• Familiarity with eukaryotic cell culture and standard cell biology techniques.
• Strong organizational skills, attention to detail, and ability to work both independently and collaboratively.
• Evidence of research contributions through publications or presentations.
• (Preferred) Experience in a core imaging facility or collaborative research setting.
• (Preferred) Familiarity with TEM protocols for mammalian and other eukaryotic biological samples.
• (Preferred) Experience with CLEM workflows.
• (Preferred) Basic skills in microscopy image analysis and quantitative data processing.

To Apply

Applicants should submit:

• A CV including publications
• A cover letter describing relevant experience in cell biology, TEM, and bioimaging
• Contact details for two to three professional references

This position offers an excellent opportunity to apply and expand TEM expertise in a collaborative research environment, contributing to high-resolution studies of mechanobiology, aging, and cell–microenvironment interactions. Salary and benefits will be commensurable to the educational qualifications and working experience of candidates. We regret that only shortlisted candidates will be notified.

More Information

Location: Kent Ridge Campus

Organization: Mechanobiology Institute

Department : Research

Employee Referral Eligible: No

Job requisition ID : 30004