Research Fellow (Genome Editing)

Job Description

We are seeking talented postdoctoral or research fellows to join the Genome Re-InnovaTion-Lab (https://grit-lab.org/), part of Synthetic Biology Translational Research Programme (TRP) at the National University of Singapore Yong Loo Lin School of Medicine. The Synthetic Biology TRP aims to develop novel genome editing tools, specifically by engineering existing CRISPRs, enhancing functionality through combinations with other enzymes, and screening desired mutants from the library via directed evolution.

The Research Fellow/s (RFs) will collaborate closely with the Principal Investigator and the research team to develop CRISPR tools. Appointments will initially be made on a 1-year contract, with the possibility of extension. PhD holders with no experience are welcome to apply.

The Research Fellow is expected to:

1. Rationally design protein engineering sites and conduct various library generation experiments (e.g., error-prone PCR, site saturation mutation) to create a library with high diversity;
2. Test CRISPR in various mammalian cell lines and measure indel efficiencies using Next Generation Sequencing tools;
3. Mentor research assistants, graduate, and undergraduate students;
4. Assist in any other duties delegated by the Principal Investigator and group leaders.

Qualifications

The applicant should:

1. Hold a PhD in Biotechnology, Biological Sciences, Biochemistry, or related disciplines;
2. Have extensive knowledge and hands-on experience on genetic parts assembly, pathway engineering, microbial strain engineering, fermentation, recovery and analytics of targeted metabolites;
3. Have the ability to design and perform experiments for microbial strain engineering, gene expression, protein expression, enzymatic assays, microbial fermentation, and product recovery;
4. Know how to work independently and in a team, have an investigative nature and a strong attention to detail;
5. Possess an established record of international publications

Remuneration will be commensurate to the candidate's qualifications and experience. Informal enquiries are welcome and should be made to

Ms Suhana Sulaiman, at suhana_s@nus.edu.sg

Formal application: Please submit your application, indicating job reference number and current/expected salary, supported by a detailed CV (including personal particulars, academic and employment history, complete list of publications/oral presentations and full contacts of 3 referees). Only shortlisted candidates will be notified.

More Information

Location: Kent Ridge Campus

Organization: Yong Loo Lin School of Medicine

Department : Dean-Med-Synthetic Biology Translational Research Programme

Employee Referral Eligible: No

Job requisition ID : 25324