Research Assistant (Cancer Science Institute)

Job Summary

Cancer Science Institute of Singapore (CSI) is establishing a new research lab under the leadership of Dr. Zhou Yilong. The lab will focus on RNA biology, cancer, and immunity.

We are seeking a highly motivated, dedicated and detail-oriented Research Assistant to contribute to the lab's cutting-edge research on RNA-protein interactions, biomolecular condensates, and the role of RNA helicases in cancer.  In addition to research responsibilities, the Research Assistant will play a crucial role in commissioning the lab, setting up essential equipment, and ensuring operational readiness.

Duties and Responsibilities

Laboratory:

• Assist in the design, execution, and analysis of experiments related to RNA and cell biology and immune response mechanisms.
• Commission Dr. Zhou Yilong’s lab, including setting up research equipment, managing inventory, and ensuring all operational protocols are in place.
• Perform RNA isolation, sequencing, and bioinformatic analyses to explore RNA sequence modifications and their implications for cancer and viral infections.
• Support the development of tumor models to study RNA dynamics in cancer and infection diseases.
• Apply molecular techniques, including new CRISPR/Cas9, iCLIP, and FANCI technology from the PI, to isolate and study RNA condensates like stress granules, P bodies and nuclear speckles.

Data Management & Analysis:

• Maintain accurate records of experimental procedures, results, and data analysis for reports, publications, and presentations.
• Assist in the preparation of research publications, reports, and presentations.

General Support:

• Collaborate with other Translational Research Teams aimed at improving mRNA vaccines and developing RNA-based cancer therapies.
• Present findings at lab meetings and scientific conferences.
• Provide administrative support in grant applications, ethics board submissions, and meeting coordination.

Qualifications

• Bachelor’s or Master’s degree in Molecular Biology, Biochemistry, Cancer Biology, or a related field.
• Prior experience with lab setup, equipment management, or commissioning of research facilities.
• Strong skills in molecular biology techniques (e.g., RNA isolation, PCR, cell culture, CRISPR).
• Knowledge of RNA biology, cancer biology, or immunology is advantageous.
• Familiarity with bioinformatics tools for RNA sequencing analysis is a plus.
• Strong organizational skills and attention to detail.
• Ability to work both independently and as part of a team.

Preferred Experience:

• Experience with RNA helicases, biomolecular condensates, deep-sequencing and proteomic techniques.
• Prior involvement in lab commissioning or management.
• Familiarity with cancer models and translational research in RNA therapeutics in cell and animal level.