Job Description

The ADJ Laboratory at Cancer Science Institute, focuses on understanding the immune system's recognition of cancer cells after DNA-damaging chemotherapy. The lab’s goal is to guide the rational design of immunotherapy-chemotherapy combinations for cancer treatment, with a particular emphasis on lymphomas and collaborations with the NUH Lymphoma team. The Research Fellow will play a pivotal role in advancing these efforts by conducting cutting-edge research at the intersection of molecular and cellular biology, immunology, and translational cancer therapy.

1. Conduct Research:

   • Investigate intracellular mechanisms in cancer cells influencing immune activation after DNA damage.
   • Develop and evaluate combination strategies to enhance the efficacy of genotoxic chemotherapy using cell-intrinsic and cell-extrinsic approaches.

2. Experimental Design and Execution:

   • Utilize cell line models for epithelial and lymphoid cancers to study DNA repair and immune activation mechanisms.
   • Design and perform in-vitro assays and systems to analyze immunogenic responses to chemotherapy.
   • Perform quantitative microscopy on histological material to explore immune modulation pathways.

3. Data Analysis and Dissemination:

   • Analyze experimental results, interpret findings, and prepare research publications in high-impact journals.
   • Present research outcomes at local and international conferences.

4. Collaborations:

   • Work closely with local and international collaborators for clinical sample acquisition and analysis.
   • Partner with pharmaceutical and medical technology companies to facilitate clinical translation and biomarker development.

5. Mentorship and Supervision:

   • Provide guidance and mentorship to graduate students, post-doctoral researchers, elective students, and medical trainees involved in the lab’s projects.

6. Research Development:

   • Contribute to securing research funding through grant proposals and fostering academic-industry collaborations.

Qualifications

• Education and Experience:

  • Ph.D. in Molecular Biology, Immunology, Cancer Biology, or a related field.
  • Experience in translational cancer research and familiarity with immune-oncology.

• Technical Skills:

  • Proficiency in cell culture, molecular biology, and immunological assays.
  • Experience with DNA repair assays, flow cytometry, and quantitative microscopy.
  • Competence in bioinformatics and data analysis tools will be advantageous.

• Soft Skills:

  • Strong analytical and problem-solving abilities.
  • Excellent communication skills and the ability to work collaboratively in a diverse team.
  • Commitment to promoting diversity and mutual respect in science.

• Additional Attributes:

  • Proven track record of scientific publications and presentations.
  • Ability to manage multiple projects and meet deadlines.
  • Familiarity with clinical sample handling and translational research methodologies.