Job Description

The Research Fellow will have opportunities to work with well-characterised clinical samples, state-of-the-art laboratory platforms, and an extensive network of local and international collaborators while contributing to high-impact publications and future clinical translation.

Key Responsibilities

• Design, plan, and execute independent research projects aligned with the laboratory's scientific objectives.
• Investigate mechanisms by which DNA damage and DNA repair defects influence innate and adaptive immune responses in cancer.
• Study immunogenic cell death, cytosolic nucleic acid sensing pathways, and tumour immune microenvironment modulation following genotoxic chemotherapy.
• Develop and optimise molecular and cellular assays related to DNA repair, immune activation, and cancer biology.
• Perform and interpret experiments using cell line models of epithelial and lymphoid malignancies.
• Apply quantitative microscopy and histopathological imaging techniques to investigate immune modulation pathways in human tumour samples.
• Analyse and interpret complex experimental datasets using appropriate statistical and computational approaches.
• Collaborate with clinicians and translational researchers to analyse patient-derived clinical specimens and develop clinically relevant biomarkers.
• Contribute to the design and evaluation of novel chemotherapy-immunotherapy combination strategies.
• Prepare manuscripts for publication in peer-reviewed journals and present findings at scientific conferences.
• Assist in preparing research grant applications and progress reports.
• Mentor graduate students, research assistants, and junior laboratory members where appropriate.
• Contribute to laboratory management, protocol development, and maintenance of high standards of scientific integrity and research compliance.
• Foster a collaborative, respectful, and inclusive research culture.

Qualifications

• PhD in Cancer Biology, Immunology, Molecular Biology, Cell Biology, Biomedical Sciences, Genetics, or a related discipline.
• Strong publication record in peer-reviewed scientific journals.
• Demonstrated expertise in one or more of the following:
  • DNA damage response and DNA repair biology
  • Cancer immunology
  • Molecular and cellular biology
  • Immunofluorescence and quantitative microscopy
  • Flow cytometry
  • CRISPR/Cas9 genome editing
  • Genomic and transcriptomic analyses
  • Cancer cell culture and functional assays
• Experience working with animal models and/or human clinical specimens would be advantageous.
• Familiarity with bioinformatics or computational analysis of biological datasets is desirable.
• Excellent scientific writing, presentation, and communication skills.
• Ability to work both independently and collaboratively within multidisciplinary teams.